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Lyell Immunopharma

1.17 USD
-0.01
0.85%
At close Oct 18, 4:00 PM EDT
After hours
1.17
+0.00
0.00%
1 day
-0.85%
5 days
0.00%
1 month
-13.33%
3 months
-28.22%
6 months
-49.79%
Year to date
-44.55%
1 year
-25.95%
5 years
-93.07%
 

About: Lyell Immunopharma Inc is a clinical-stage cell therapy company. It has a pipeline of product candidates for patients with solid tumors utilizing ex vivo genetic and epigenetic T-cell reprogramming technologies. The company's product pipeline includes, LYL797, LYL119, LYL845 among others.

Employees: 224

0
Funds holding %
of 6,740 funds
Analysts bullish %

Fund manager confidence

Based on 2024 Q2 SEC filings by fund managers ($100M+ AUM)

21% more call options, than puts

Call options by funds: $17K | Put options by funds: $14K

0% more funds holding in top 10

Funds holding in top 10: 4 [Q1] → 4 (+0) [Q2]

0.15% less ownership

Funds ownership: 52.45% [Q1] → 52.3% (-0.15%) [Q2]

6% less funds holding

Funds holding: 125 [Q1] → 118 (-7) [Q2]

23% less repeat investments, than reductions

Existing positions increased: 34 | Existing positions reduced: 44

30% less first-time investments, than exits

New positions opened: 16 | Existing positions closed: 23

35% less capital invested

Capital invested by funds: $298M [Q1] → $194M (-$104M) [Q2]

Research analyst outlook

1 Wall Street Analyst provided 1 year price targets over the past 3 months

Low target
$1
15%
downside
Avg. target
$1
15%
downside
High target
$1
15%
downside

1 analyst rating

positive
0%
neutral
100%
negative
0%
HC Wainwright & Co.
Mitchell Kapoor
50% 1-year accuracy
66 / 133 met price target
15%downside
$1
Neutral
Reiterated
19 Aug 2024

Financial journalist opinion

Neutral
GlobeNewsWire
3 months ago
Lyell Immunopharma Reports Dose-dependent Clinical Activity from Phase 1 Trial of LYL797, a ROR1-targeted CAR-T Cell Product Candidate Enhanced with its Proprietary Anti-exhaustion Technology
SOUTH SAN FRANCISCO, Calif., June 26, 2024 (GLOBE NEWSWIRE) -- Lyell Immunopharma, Inc. (Nasdaq: LYEL), a clinical‑stage T-cell reprogramming company advancing a diverse pipeline of cell therapies for patients with solid tumors, today announced initial clinical and translational data from its Phase 1 trial of LYL797, its first-generation reprogrammed ROR1 CAR T‑cell product candidate enhanced with proprietary anti-exhaustion technology. The initial dataset consists primarily of patients with triple-negative breast cancer (TNBC) and demonstrated dose-dependent antitumor clinical activity and the ability of LYL797 CAR T cells to proliferate, infiltrate tumors and kill cancer cells in patients with relapsed/refractory disease. Patients with TNBC treated with LYL797 had an objective response rate (ORR) of 40% and clinical benefit rate (CBR) of 60% at the 150 x 106 CAR T cell dose level, with a CBR of 38% across all dose levels evaluable to date. Common treatment-related adverse events in patients without lung metastases included Grade 1 and 2 cytokine release syndrome (CRS) and headache, and the expected cytopenia from lymphodepletion. There were no reports of immune effector cell-associated neurotoxicity syndrome (ICANS) attributed to LYL797. Pneumonitis occurred in patients with lung metastases and dose escalation is continuing separately and more gradually in those patients. No dose-limiting toxicities have been reported in patients without lung involvement. All patients are now receiving prophylactic steroids prior to LYL797 treatment.
Lyell Immunopharma Reports Dose-dependent Clinical Activity from Phase 1 Trial of LYL797, a ROR1-targeted CAR-T Cell Product Candidate Enhanced with its Proprietary Anti-exhaustion Technology
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