DNLI icon

Denali Therapeutics

21.93 USD
+0.26
1.20%
At close Jan 17, 4:00 PM EST
After hours
21.93
+0.00
0.00%
1 day
1.20%
5 days
15.36%
1 month
-5.56%
3 months
-20.02%
6 months
-4.69%
Year to date
5.23%
1 year
28.10%
5 years
-1.92%
10 years
2.24%
 

About: Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegeneration disease. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, DNL747, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others.

Employees: 390

0
Funds holding %
of 6,823 funds
0
Analysts bullish %
of 5 analysts

Fund manager confidence

Based on 2024 Q3 regulatory filings by fund managers ($100M+ AUM)

76% more first-time investments, than exits

New positions opened: 37 | Existing positions closed: 21

72% more call options, than puts

Call options by funds: $2.01M | Put options by funds: $1.17M

33% more repeat investments, than reductions

Existing positions increased: 77 | Existing positions reduced: 58

31% more capital invested

Capital invested by funds: $2.81B [Q2] → $3.69B (+$875M) [Q3]

7% more funds holding

Funds holding: 201 [Q2] → 215 (+14) [Q3]

3.52% more ownership

Funds ownership: 84.89% [Q2] → 88.41% (+3.52%) [Q3]

50% less funds holding in top 10

Funds holding in top 10: 2 [Q2] → 1 (-1) [Q3]

Research analyst outlook

5 Wall Street Analysts provided 1 year price targets over the past 3 months

Low target
$24
9%
upside
Avg. target
$45
104%
upside
High target
$87
297%
upside

5 analyst ratings

positive
100%
neutral
0%
negative
0%
JP Morgan
Jessica Fye
47% 1-year accuracy
18 / 38 met price target
9%upside
$24
Overweight
Maintained
7 Jan 2025
HC Wainwright & Co.
Andrew Fein
32% 1-year accuracy
109 / 339 met price target
297%upside
$87
Buy
Maintained
7 Jan 2025
Baird
Joel Beatty
48% 1-year accuracy
20 / 42 met price target
41%upside
$31
Outperform
Initiated
7 Jan 2025
Stifel
Paul Mattels
0% 1-year accuracy
0 / 1 met price target
69%upside
$37
Buy
Upgraded
16 Dec 2024
Jefferies
Michael Yee
10% 1-year accuracy
1 / 10 met price target
105%upside
$45
Buy
Maintained
1 Nov 2024

Financial journalist opinion

Based on 8 articles about DNLI published over the past 30 days

Neutral
Benzinga
5 days ago
Why Is Denali Therapeutics Stock Trading Higher On Wednesday?
Denali Therapeutics Inc DNLI CEO Ryan Watts presented at the J.P. Morgan Healthcare Conference.
Why Is Denali Therapeutics Stock Trading Higher On Wednesday?
Negative
Seeking Alpha
1 week ago
Denali: Despite ALS Primary Endpoint Failure, Possible Path Forward Remains
Denali Therapeutics Inc.'s DNL343 failed to meet the primary endpoint in the phase 2/3 HEALY ALS trial, but potential biomarker analyses in 2025 may offer a path forward. Despite the trial setback in ALS, Denali's stock remains stable due to continued pre-specified analyses expected in late 2025. BLA filing of tividenofusp alfa for the treatment of patients with MPS II remains on track under the Accelerated Approval Pathway Program in early 2025.
Denali: Despite ALS Primary Endpoint Failure, Possible Path Forward Remains
Positive
Zacks Investment Research
1 week ago
DNLI's Hunter Syndrome Drug Gets Breakthrough Therapy Designation
Denali obtains Breakthrough Therapy Designation for its experimental candidate, tividenofusp alfa (DNL310), for the treatment of pateints with Hunter syndrome.
DNLI's Hunter Syndrome Drug Gets Breakthrough Therapy Designation
Negative
Zacks Investment Research
1 week ago
Denali's ALS Study Fails to Meet Primary and Secondary Endpoints
DNLI's DNL343 fails to achieve the primary and secondary endpoints, as observed from an analysis of Regimen G of the phase II/III HEALEY ALS platform trial.
Denali's ALS Study Fails to Meet Primary and Secondary Endpoints
Positive
Investors Business Daily
1 week ago
Denali Reverses Its Fortunes With 'Too Early' Miss In ALS Treatment
Denali Therapeutics shares reversed higher on Tuesday after the drugmaker's ALS treatment failed in a six-month study. The post Denali Reverses Its Fortunes With 'Too Early' Miss In ALS Treatment appeared first on Investor's Business Daily.
Denali Reverses Its Fortunes With 'Too Early' Miss In ALS Treatment
Negative
Reuters
2 weeks ago
Denali Therapeutics ALS drug fails in mid-stage trial
Denali Therapeutics said on Monday its experimental drug failed to meet the main goal of a mid-to-late stage trial in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.
Denali Therapeutics ALS drug fails in mid-stage trial
Neutral
GlobeNewsWire
2 weeks ago
Denali Therapeutics Announces Topline Results for Regimen G Evaluating eIF2B Agonist DNL343 in the Phase 2/3 HEALEY ALS Platform Trial
SOUTH SAN FRANCISCO, Calif., Jan. 06, 2025 (GLOBE NEWSWIRE) -- Denali Therapeutics Inc. (NASDAQ: DNLI) today announced topline results from an analysis of Regimen G of the Phase 2/3 HEALEY ALS Platform Trial evaluating eIF2B agonist DNL343 in the treatment of amyotrophic lateral sclerosis (ALS).
Denali Therapeutics Announces Topline Results for Regimen G Evaluating eIF2B Agonist DNL343 in the Phase 2/3 HEALEY ALS Platform Trial
Positive
Benzinga
2 weeks ago
Denali Therapeutics Neurodegenerative Disease Platform Sparks Analyst Optimistic
William Blair has initiated coverage on Denali Therapeutics Inc DNLI, a company focused on developing drugs for neurodegenerative diseases.
Denali Therapeutics Neurodegenerative Disease Platform Sparks Analyst Optimistic
Negative
Zacks Investment Research
1 month ago
Why Is Denali Therapeutics (DNLI) Down 21.2% Since Last Earnings Report?
Denali Therapeutics (DNLI) reported earnings 30 days ago. What's next for the stock?
Why Is Denali Therapeutics (DNLI) Down 21.2% Since Last Earnings Report?
Neutral
Zacks Investment Research
1 month ago
Denali Starts Dosing in Phase II Parkinson's Disease Study
DNLI begins dosing in the phase IIa study on BIIB122 in approximately 50 participants with Parkinson's disease and LRRK2 pathogenic mutations confirmed by genetic testing.
Denali Starts Dosing in Phase II Parkinson's Disease Study
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