LPTX icon

Leap Therapeutics

0.3634 USD
-0.0056
1.52%
At close Apr 17, 4:00 PM EDT
1 day
-1.52%
5 days
18.56%
1 month
-14.45%
3 months
-85.75%
6 months
-84.40%
Year to date
-88.71%
1 year
-87.89%
5 years
-97.91%
10 years
-99.54%
 

About: Leap Therapeutics Inc is a biopharmaceutical company developing novel biomarker-targeted antibody therapies designed to treat patients with cancer by inhibiting fundamental tumor-promoting pathways, targeting cancer-specific cell surface molecules, and harnessing the immune system to attack cancer cells. The company's key clinical-stage drug candidate is sirexatamab (DKN-01), which targets Dickkopf-related protein 1 (DKK1) and is being studied in a clinical trial in patients with colorectal cancer. In addition, it also has a preclinical program to develop a proprietary monoclonal antibody, called FL-501 which works by inhibiting the GDF-15 protein.

Employees: 52

0
Funds holding %
of 7,407 funds
Analysts bullish %

Fund manager confidence

Based on 2024 Q4 regulatory disclosures by fund managers ($100M+ AUM)

186% more repeat investments, than reductions

Existing positions increased: 20 | Existing positions reduced: 7

150% more first-time investments, than exits

New positions opened: 15 | Existing positions closed: 6

47% more capital invested

Capital invested by funds: $37.8M [Q3] → $55.6M (+$17.8M) [Q4]

19% more funds holding

Funds holding: 48 [Q3] → 57 (+9) [Q4]

11.99% more ownership

Funds ownership: 38.46% [Q3] → 50.46% (+11.99%) [Q4]

70% less call options, than puts

Call options by funds: $43K | Put options by funds: $142K

Research analyst outlook

We haven’t received any recent analyst ratings for LPTX.

Financial journalist opinion

Based on 5 articles about LPTX published over the past 30 days

Neutral
PRNewsWire
4 days ago
Leap Therapeutics to Host Virtual KOL Event to Discuss Sirexatamab (DKN-01) in Second-line Patients with Advanced Microsatellite Stable Colorectal Cancer
Virtual KOL Event on Wednesday, April 23, 2025, at 2:30 p.m. ET CAMBRIDGE, Mass.
Leap Therapeutics to Host Virtual KOL Event to Discuss Sirexatamab (DKN-01) in Second-line Patients with Advanced Microsatellite Stable Colorectal Cancer
Neutral
Seeking Alpha
2 weeks ago
Leap Therapeutics (LPTX) Conference Call to discuss Updated Data from Part B of the DeFianCe Study Transcript
Leap Therapeutics (NASDAQ:LPTX ) Conference Call to discuss Updated Data from Part B of the DeFianCe Study March 26, 2025 8:00 AM ET Company Participants Douglas Onsi - President and CEO Cyndi Sirard - Chief Medical Officer Jason Baum - Chief Scientific Officer Conference Call Participants Matthew Pipps - William Blair Swayampakula Ramakanth - H.C. Wainwright Operator Good morning.
Leap Therapeutics (LPTX) Conference Call to discuss Updated Data from Part B of the DeFianCe Study Transcript
Positive
Benzinga
3 weeks ago
Penny Stock Leap Therapeutics Unveils Positive Data From Experimental Combo Therapy For Colorectal Cancer
Leap Therapeutics, Inc.  LPTX presented updated preliminary data on Wednesday from Part B of the DeFianCe Phase 2 trial of sirexatamab (DKN-01) in combination with bevacizumab and chemotherapy (Experimental Arm) compared to bevacizumab and chemotherapy (Control Arm).
Penny Stock Leap Therapeutics Unveils Positive Data From Experimental Combo Therapy For Colorectal Cancer
Neutral
PRNewsWire
3 weeks ago
Leap Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results
Leap to host a conference call to present updated CRC clinical data today, March 26, 2025, at 8:00 a.m. ET CAMBRIDGE, Mass.
Leap Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results
Neutral
PRNewsWire
3 weeks ago
Leap Therapeutics Reports Positive Updated Data from Sirexatamab Colorectal Cancer Study
Updated data confirms statistically significant 32% higher ORR and 3.5 month longer PFS  in second-line CRC patients with high DKK1 levels treated with sirexatamab plus bevacizumab and chemotherapy Statistically significant 22% higher ORR and 2.6 month longer PFS in patients who had not had prior anti-VEGF therapy Leap to host a conference call to present clinical data today, March 26, 2025, at 8:00 a.m. ET CAMBRIDGE, Mass.
Leap Therapeutics Reports Positive Updated Data from Sirexatamab Colorectal Cancer Study
Neutral
PRNewsWire
2 months ago
Leap Therapeutics Reports Initial Clinical Data from Part B of the DeFianCe Study and Part C of the DisTinGuish Study
35% objective response rate (ORR) in second-line colorectal cancer (CRC) patients treated with sirexatamab (DKN-01) plus bevacizumab and chemotherapy, compared to 23% ORR in the control arm DKK1 levels highly correlated with clinical activity in CRC population ORR benefit with sirexatamab observed across multiple potential Phase 3 CRC populations Preparations will begin for a registrational Phase 3 study in second-line CRC patients DisTinGuish Part C study in gastric cancer demonstrates activity in biomarker populations,  but not the signal necessary to advance into Phase 3 Leap to host a conference call to present clinical data today, January 28, 2025, at 8:00 a.m. ET CAMBRIDGE, Mass.
Leap Therapeutics Reports Initial Clinical Data from Part B of the DeFianCe Study and Part C of the DisTinGuish Study
Positive
Seeking Alpha
3 months ago
Leap Therapeutics: A Buy On Near-Term Data Catalysts In Stomach And Colon Cancer
Leap Therapeutics focuses on developing DKN-01, a promising monoclonal antibody for solid tumors, with encouraging early trial data in GI cancers. LPTX has a short operational runway with less than a year's worth of funds, making future funding a critical concern. Key phase 2 trial readouts for DKN-01 are expected in 2025, which could significantly impact the company's valuation and investment potential.
Leap Therapeutics: A Buy On Near-Term Data Catalysts In Stomach And Colon Cancer
Neutral
PRNewsWire
3 months ago
Leap Therapeutics to Participate at the 43rd Annual J.P. Morgan Healthcare Conference
CAMBRIDGE, Mass. , Jan. 6, 2025 /PRNewswire/ -- Leap Therapeutics, Inc. (Nasdaq:LPTX), a biotechnology company focused on developing targeted and immuno-oncology therapeutics, today announced that Douglas E.
Leap Therapeutics to Participate at the 43rd Annual J.P. Morgan Healthcare Conference
Neutral
PRNewsWire
4 months ago
Leap Therapeutics to Participate at Piper Sandler 36th Annual Healthcare Conference
CAMBRIDGE, Mass. , Nov. 26, 2024 /PRNewswire/ -- Leap Therapeutics, Inc. (Nasdaq:LPTX), a biotechnology company focused on developing targeted and immuno-oncology therapeutics, today announced that Douglas E.
Leap Therapeutics to Participate at Piper Sandler 36th Annual Healthcare Conference
Neutral
PRNewsWire
5 months ago
Leap Therapeutics Reports Third Quarter 2024 Financial Results
CAMBRIDGE, Mass. , Nov. 13, 2024 /PRNewswire/ -- Leap Therapeutics, Inc. (Nasdaq:LPTX), a biotechnology company focused on developing targeted and immuno-oncology therapeutics, today reported financial results for the third quarter ended September 30, 2024.
Leap Therapeutics Reports Third Quarter 2024 Financial Results
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